The dosage of thiopental as pharmacological cerebral protection during non-shunt carotid endarterectomy: A retrospective study

Background: Thiopental has been used as a pharmacological cerebral protection strategy during carotid endarterectomy surgeries. However, the optimal dosage required to induce burst suppression on electroencephalogram (EEG) remains unknown. This retrospective study aimed determine of thiopental non-shunt endarterectomy. Methods: The Neurological Institute Thailand Review Board approved study. Data were collected from 2009 2019 for all patients who received and had intraoperative EEG monitoring. Demographic information, stenosis severity, parameters, dosage, clamp time, events, patient outcomes abstracted. Results: included 57 patients. Among them, 24 (42%) achieved pattern with 26.3+10.1 mg/kg/hr. There no significant differences in perioperative events between those did not. After surgery, 33.3% extubated awakened. One non-burst group experienced mild neurological deficits. No deaths occurred within one month postoperative. Conclusions: achieve was mg/kg/hr.